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Design, synthesis and structure–activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression

✍ Scribed by Radhakrishnan Mahesh; Thangaraj Devadoss; Dilip Kumar Pandey; Shvetank Bhatt; Shushil Kumar Yadav


Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
213 KB
Volume
20
Category
Article
ISSN
0960-894X

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✍ Radhakrishnan Mahesh; Thangaraj Devadoss; Dilip Kumar Pandey; Shvetank Bhatt 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 281 KB

A novel series of 3-ethoxyquinoxalin-2-carboxamides were designed as per the pharmacophoric requirements of 5-HT 3 receptor antagonist using ligand-based approach. The desired carboxamides were synthesized from the key intermediate, 3-ethoxyquinoxalin-2-carboxylic acid by coupling with appropriate a