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Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase

✍ Scribed by McHardy, Stanton F.; Bohmann, Jonathan A.; Corbett, Michael R.; Campos, Bismarck; Tidwell, Michael W.; Thompson, Paul Marty; Bemben, Chris J.; Menchaca, Tony A.; Reeves, Tony E.; Cantrell, William R.; Bauta, William E.; Lopez, Ambrosio; Maxwell, Donald M.; Brecht, Karen M.; Sweeney, Richard E.; McDonough, John


Book ID
121668309
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
621 KB
Volume
24
Category
Article
ISSN
0960-894X

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## Abstract Nine potential AChE reactivators were synthesized using modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by cyclosarin nerve agent was tested in vitro. According to the previous results, 1,4-bis(2-hydroxyiminomethylpyridinium)butane dibromid