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Design, Synthesis, and Biological Evaluation of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inhibitor

✍ Scribed by Rano, Thomas; Pelton, Patricia; Demarest, Keith T.; Gibbs, Alan C.; Murray, William V.; Damiano, Bruce P.; Connelly, Margery A.; Kuo, Gee-Hong


Book ID
111966432
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
787 KB
Volume
52
Category
Article
ISSN
0022-2623

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An efficient and scalable synthesis of (
✍ Aihua Wang; Yan Zhang; Songfeng Lu; William V. Murray; Gee-Hong Kuo 📂 Article 📅 2010 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 140 KB

## Abstract magnified image An efficient and scalable synthesis of the potent CETP inhibitor, (2__R__,α__S__)‐3,4‐dihydro‐2‐[3‐(1,1,2,2‐tetrafluoroethoxy)phenyl]‐5‐[3‐(trifluoromethoxy)phenyl]‐α‐(trifluoromethyl)‐1(2__H__)‐quinolineethanol 1, is described. One of the important intermediates, tetrah