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Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides

✍ Scribed by Maurizio Quintiliani; Leentje Persoons; Nicola Solaroli; Anna Karlsson; Graciela Andrei; Robert Snoeck; Jan Balzarini; Christopher McGuigan

Book ID
108073033
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
441 KB
Volume
19
Category
Article
ISSN
0968-0896

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✍ Pieter E. Joos; Eddy L. Esmans; Roger A. Dommisse; André De Bruyn; Jan M. Balzar 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 German ⚖ 549 KB

## Abstract A new protected 2‐deoxy‐D‐ribose derivative, 5‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐deoxy‐3,4‐__O__‐ isopropylidene‐__aldehydo__‐D‐ribose (5), was synthesized starting from 2‐deoxy‐D‐ribose. This compound was coupled with 2‐lithio‐4‐(4,5‐dihydro‐4,4‐dimethyloxazol‐2‐yl)pyridine givin