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Synthesis and Biological Evaluation of Butanoate, Retinoate, and Bis(2,2,2-trichloroethyl)phosphate Derivatives of 5-Fluoro-2′-deoxyuridine and 2′,5-Difluoro-2′-deoxyuridine as Potential Dual Action Anticancer Prodrugs

✍ Scribed by Zuping Xia; Leonard I. Wiebe; Gerald G. Miller; Edward E. Knaus


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
126 KB
Volume
332
Category
Article
ISSN
0365-6233

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✍ Hugo Cerecetto; Mercedes González; Mariela Risso; Gustavo Seoane; Adela López de 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB 👁 2 views

Several new 1,2,5-oxadiazole N-oxide derivatives were synthesized to be tested both as potential selective hypoxic cell cytotoxins and as DNA-binding agents. The compounds prepared included bis(1,2,5-oxadiazole N-oxide) derivatives and oxadiazole rings linked to naphthyl residues. The compounds were