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Design, synthesis and biological activity of protaxols

โœ Scribed by Nicolaou, K. C.; Riemer, C.; Kerr, M. A.; Rideout, D. R.; Wrasidlo, W. W.

Book ID
109784836
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
373 KB
Volume
364
Category
Article
ISSN
0028-0836

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Design and synthesis of new taxol-contai
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Taxol-containing aminophosphates 5-7 were synthesized as protaxols by a "oneflask" method; the intrinsic zwitterionic character increases their solubility to about six times higher than that of taxol in a phosphate buffer solution.