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Design and synthesis of new taxol-containing aminophosphates as protaxols

✍ Scribed by Jih Ru Hwu; Gholam H. Hakimelahi; Thota Sambaiah; Himatkumar V. Patel; Shwu-Chen Tsay; Yiu-Kay Lai; Chien-Hui Lieu

Book ID: 104364872
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 185 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00058-9

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✦ Synopsis

Taxol-containing aminophosphates 5-7 were synthesized as protaxols by a "oneflask" method; the intrinsic zwitterionic character increases their solubility to about six times higher than that of taxol in a phosphate buffer solution.

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