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Design, synthesis and antitumor activity of novel 8-substituted 2,3,5,6-tetrahydrobenzo[1,2-b:4,5-b′]difuran imidazolium salt derivatives

✍ Scribed by Sun, Cheng-Jun; Chen, Wen; Li, Yan; Liu, Lan-Xiang; Wang, Xue-Quan; Li, Li-Juan; Zhang, Hong-Bin; Yang, Xiao-Dong


Book ID
126452852
Publisher
The Royal Society of Chemistry
Year
2014
Tongue
English
Weight
998 KB
Volume
4
Category
Article
ISSN
2046-2069

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## Abstract We developed a versatile synthesis of tetraaryl‐substituted benzo[1,2‐__b__:5,4‐__b__′]difurans (__m__‐BDFs) via a zinc‐mediated intramolecular double cyclization reaction of 4,6‐bis(phenylethynyl)‐1,3‐benzenediol, followed by a palladium‐catalyzed cross‐coupling reaction. In comparison