Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives
โ Scribed by Wei Zhang; Wenlu Liu; Xizhen Jiang; Faqin Jiang; Hao Zhuang; Lei Fu
- Book ID
- 113582968
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- French
- Weight
- 631 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0223-5234
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## Abstract The reaction of ethyl 4โ(benzofuranโ2โyl)โ2,4โdioxobutanoate **2** with two moles of hydrazine hydrate afforded 5โ(benzofuranโ2โyl)โ1__H__โpyrazoleโ3โcarbohydrazide **4a**, while its reaction with equimolar amount of phenylhydrazine gave ester **3b** which then converted to 5โ(benzofura
A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity u