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Design of Peptides with α,β-Dehydro Residues: Synthesis, Crystal Structure and Molecular Conformation of a Peptide N-Boc-Phe-ΔPhe-Ile-OCH3

✍ Scribed by R. Vijayaraghavan; V. K. Goel; S. Dey; T. P. Singh

Publisher
Springer
Year
2005
Tongue
English
Weight
446 KB
Volume
16
Category
Article
ISSN
1040-0400

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To obtain general rules of peptide design using alpha, beta-dehydro-residues, a sequence with two consecutive delta Phe-residues, Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3, was synthesized by azlactone method in solution phase. The peptide was crystallized form its solution in an acetone/water mixtur

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✍ Sharmistha Dey; Shome Nath Mitra; Tej P. Singh 📂 Article 📅 1998 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 591 KB

The peptide BOC-L-Val-APhe-APhe-L-Val-OCH3 was synthesized by the azlactone method in solution phase, and its crystal and molecular structures were determined by x-ray diffraction method. Single crystals were grown by slow evaporation from a methanol/water solution at 6°C. The crystals belong to an

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Design of peptides: Crystal and molecular structure of a 310-helical peptide N-Boc-L-Phe-dehydro-Phe-L-Val-L-Phe-dehydro-Phe-L-Val-Och3
✍ B. Padmanabhan; T. P. Singh 📂 Article 📅 1993 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 536 KB

Highly specific peptide structures can be designed by inserting dehydro residues into peptide sequences. The peptide N-Boc-L-Phe-dehydro-Phe-L-Val-L-Phe-dehydro-Phe-~-V~-OCH~, synthesized by conventional procedures, crystallizes from methanol-water mixtures at 4°C in the tetragonal space group P43 w

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Design of peptides: Synthesis, crystal structure, molecular conformation, and conformational calculations of N-Boc-L-Phe-Dehydro-Ala-OCH3
✍ B. Padmanabhan; S. Dey; B. Khandelwal; G. Subba Rao; T. P. Singh 📂 Article 📅 1992 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 505 KB

## Abstract It is noteworthy that the dehydro‐Ala residue adopts an extended conformation that is different than those observed in dehydro‐Phe, dehydro‐Leu, and dehydro‐Abu. The peptide N‐Boc‐L ‐Phe‐dehydro‐Ala‐OCH~3~ (C~18~H~24~N~2~O~5~) was synthesized by the usual workup procedure and finally by

α,β-Dehydro-amino acid residues in the d
α,β-Dehydro-amino acid residues in the design of peptide structures: Synthesis, crystal structure, and molecular conformation of two homologous peptides—N-Ac-Dehydro-Phe-L-Leu-OCH3 and N-Ac-Dehydro-Phe-NorVal-OCH3
✍ Pushkar Sharma; Punit Narula; Tej P. Singh 📂 Article 📅 1994 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 470 KB 👁 1 views

The dehydro-residue containing peptides N-Ac-dehydro-Phe-L-Leu-OCH3 ( I ) and N-Acdehydro-Phe-NorVal-OCH, (11) were synthesized by the usual workup procedures. The peptides crystallize from their solutions in methanol in space group P6,: ( I ) a = b = 12.528(2) A, c = 21.653(5) A; (11) a = b = 12.53