To obtain general rules of peptide design using alpha, beta-dehydro-residues, a sequence with two consecutive delta Phe-residues, Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3, was synthesized by azlactone method in solution phase. The peptide was crystallized form its solution in an acetone/water mixtur
Design of peptides with α,β-dehydro-residues: Synthesis and crystal structure of a tetrapeptide Boc-Ala-ΔPhe-ΔPhe-Phe-OCH3
✍ Scribed by Rishi K. Somvanshi; Vijay K. Goel; Sharmistha Dey; Tej P. Singh
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 383 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1572-8854
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📜 SIMILAR VOLUMES
The peptide BOC-L-Val-APhe-APhe-L-Val-OCH3 was synthesized by the azlactone method in solution phase, and its crystal and molecular structures were determined by x-ray diffraction method. Single crystals were grown by slow evaporation from a methanol/water solution at 6°C. The crystals belong to an
Using
## Abstract The structures of two dehydropentapeptides, Boc–Pro–ΔPhe–Val–ΔPhe–Ala–OMe (**I**) and Boc–Pro–ΔPhe–Gly–ΔPhe–Ala–OMe (**II**) (Boc: __t__‐butoxycarbonyl), have been determined by nuclear magnetic resonance (NMR), circular dichroism (CD), and X‐ray crystallographic studies. The peptide **