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Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase

โœ Scribed by Yu-Shun Yang; Qing-Shan Li; Shuai Sun; Yan-Bin Zhang; Xiao-Liang Wang; Fei Zhang; Jian-Feng Tang; Hai-Liang Zhu


Book ID
119203673
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
912 KB
Volume
20
Category
Article
ISSN
0968-0896

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Design and Synthesis of Some Novel 2,3,4
โœ Lianbao Ye; Yuanxin Tian; Zhonghuang Li; Jiajie Zhang; Shuguang Wu ๐Ÿ“‚ Article ๐Ÿ“… 2012 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 182 KB

## Abstract Since deregulation of the tyrosineโ€kinase receptor cโ€Met is implicated in several human cancers and is an attractive target for smallโ€moleculeโ€drug discovery, we report herein the synthesis of 2,3,4,5โ€tetrahydroโ€8โ€[1โ€(quinolinโ€6โ€ylmethyl)โ€1__H__โ€1,2,3โ€triazolo[4,5โ€__b__]pyrazinโ€6โ€yl]โ€1_