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Design and Synthesis of Some Novel 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as Potential c-Met Inhibitors

✍ Scribed by Lianbao Ye; Yuanxin Tian; Zhonghuang Li; Jiajie Zhang; Shuguang Wu

Publisher
John Wiley and Sons
Year
2012
Tongue
German
Weight
182 KB
Volume
95
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Since deregulation of the tyrosine‐kinase receptor c‐Met is implicated in several human cancers and is an attractive target for small‐molecule‐drug discovery, we report herein the synthesis of 2,3,4,5‐tetrahydro‐8‐[1‐(quinolin‐6‐ylmethyl)‐1__H__‐1,2,3‐triazolo[4,5‐b]pyrazin‐6‐yl]‐1__H__‐pyrido[4,3‐b]indoles 4a–4c and 2,3,4,5‐tetrahydro‐8‐[3‐(quinolin‐6‐ylmethyl)‐1,2,4‐triazolo[4,3‐b]pyridazin‐6‐yl]‐1__H__‐pyrido[4,3‐b]indoles 5a–5c. These indole derivatives demonstrated inhibition of c‐Met kinase activity. Concurrently, five key intermediates were synthesized. These compounds could be prepared in good yields.

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