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De novo design and in-silico studies of novel 1-phenyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid derivatives as HIV-1 reverse transcriptase inhibitors

โœ Scribed by Penta, Ashok; Chander, Subhash; Ganguly, S.; Murugesan, S.


Book ID
121544837
Publisher
Springer-Verlag
Year
2014
Tongue
English
Weight
937 KB
Volume
23
Category
Article
ISSN
1054-2523

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## Abstract Since deregulation of the tyrosineโ€kinase receptor cโ€Met is implicated in several human cancers and is an attractive target for smallโ€moleculeโ€drug discovery, we report herein the synthesis of 2,3,4,5โ€tetrahydroโ€8โ€[1โ€(quinolinโ€6โ€ylmethyl)โ€1__H__โ€1,2,3โ€triazolo[4,5โ€__b__]pyrazinโ€6โ€yl]โ€1_