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Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase

โœ Scribed by Ariamala Gopalsamy; Mengxiao Shi; Gregory Ciszewski; Kaapjoo Park; John W. Ellingboe; Mark Orlowski; Boris Feld; Anita Y.M. Howe


Book ID
108073951
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
108 KB
Volume
16
Category
Article
ISSN
0960-894X

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## Abstract Since deregulation of the tyrosineโ€kinase receptor cโ€Met is implicated in several human cancers and is an attractive target for smallโ€moleculeโ€drug discovery, we report herein the synthesis of 2,3,4,5โ€tetrahydroโ€8โ€[1โ€(quinolinโ€6โ€ylmethyl)โ€1__H__โ€1,2,3โ€triazolo[4,5โ€__b__]pyrazinโ€6โ€yl]โ€1_