Plasmodium species are the causative agents of malaria, infecting 300-660 million people annually and killing 1-2 million. Malaria is undisputedly a disease of poverty and suffers from a lack of business-driven drug research, therefore requiring new initiatives to overcome this absence of market in
✦ LIBER ✦
Design and Synthesis of Potent Inhibitors of Plasmepsin I and II: X-ray Crystal Structure of Inhibitor in Complex with Plasmepsin II
✍ Scribed by Johansson, Per-Ola; Lindberg, Jimmy; Blackman, Michael J.; Kvarnström, Ingemar; Vrang, Lotta; Hamelink, Elizabeth; Hallberg, Anders; Rosenquist, Åsa; Samuelsson, Bertil
- Book ID
- 115448425
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 334 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2623
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Malaria, a life-threatening disease caused by parasites of the genus Plasmodium, affects 500 million people annually, of which more than one million die. [1] The emergence of multi-drugresistant strains of Plasmodium falciparum, the parasite that causes the deadliest form of malaria, exacerbates the