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Design and Synthesis of Plasmepsin I and Plasmepsin II Inhibitors with Activity in Plasmodium falciparum-Infected Cultured Human Erythrocytes

✍ Scribed by Nöteberg, Daniel; Hamelink, Elizabeth; Hultén, Johan; Wahlgren, Mats; Vrang, Lotta; Samuelsson, Bertil; Hallberg, Anders


Book ID
115449071
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
391 KB
Volume
46
Category
Article
ISSN
0022-2623

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Human intraerythrocytic malarial parasites (Plasmodium falciparum) induce permeability changes in the membrane of their host cells. The differential permeability of infected erythrocytes at various stages of parasite growth, in combination with density gradient centrifugation, was used to fractionat