## Abstract A series of __O__‐alkyl iminoxylitol derivatives was synthesized and evaluated as β‐glucocerebrosidase (GCase) inhibitors. This structure–activity study shows a dramatic influence of the position of the alkyl chain (α‐C1, O2, O3, or O4) on human GCase inhibition. Remarkably, 1,2‐shift o
✦ LIBER ✦
Design and Synthesis of Highly Potent and Selective Pharmacological Chaperones for the Treatment of Gaucher's disease
✍ Scribed by Philippe Compain; Olivier R. Martin; Charlotte Boucheron; Guillaume Godin; Liang Yu; Kyoko Ikeda; Naoki Asano
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 93 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1439-4227
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