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Glycosidic Prodrugs of Highly Potent Bifunctional Duocarmycin Derivatives for Selective Treatment of Cancer

✍ Scribed by Prof. Dr. Lutz F. Tietze; Dr. J. Marian von Hof; Dipl.-Chem. Michael Müller; Dr. Birgit Krewer; Dr. Ingrid Schuberth


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
340 KB
Volume
49
Category
Article
ISSN
0044-8249

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Asymmetric Synthesis and Biological Eval
✍ Lutz F. Tietze; J. Marian von Hof; Birgit Krewer; Michael Müller; Felix Major; H 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 390 KB 👁 1 views

## Abstract A severe limitation in cancer therapy is the often insufficient differentiation between malign and benign tissue using known chemotherapeutics. One approach to decrease side effects is antibody‐directed enzyme prodrug therapy (ADEPT). We have developed new glycosidic prodrugs such as (−