๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

ChemInform Abstract: Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases

โœ Scribed by Richard B. Silverman

Publisher
John Wiley and Sons
Year
2009
Weight
15 KB
Volume
40
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Pharmacokinetics and protein binding of
Pharmacokinetics and protein binding of the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole
โœ Mark A. Bush; Gary M. Pollack ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 156 KB ๐Ÿ‘ 2 views

## Abstract Utilization of nitric oxide (NO) synthase (NOS) inhibitors to probe the role of NO in various central nervous system processes requires use of an inhibitor selective for neuronal NOS, and is facilitated by knowledge of the pharmacokinetics of the inhibitor. The present project was under

ChemInform Abstract: 2-Iminopyrrolidines
ChemInform Abstract: 2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase.
โœ T. J. HAGEN; ET AL. ET AL. ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 29 KB ๐Ÿ‘ 2 views

A series of substituted 2iminopyrrolidines is prepared and evaluated as selective inhibitors of the human inducible isoform of nitric oxide synthase (NOS). The most potent analogue is (VI). The compound (+)-(VIII) is also a good inhibitor of human inducible NOS and potent in vivo in mouse models of