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Design and synthesis of fluorine-18 labeled matrix metalloproteinase inhibitors for cancer imaging

✍ Scribed by Shozo Furumoto; Ren Iwata; Tatsuo Ido

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 130 KB
Volume: 45
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.616

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✦ Synopsis

Abstract

Matrix metalloproteinases (MMPs) are key enzymes involved in cancer invasion and metastasis. New ^18^F‐labeled MMP inhibitors (1a–c) has been designed and synthesized for cancer imaging by positron emmision tomography. The precursors were synthesized in four steps starting from D‐form of amino acids. Radiosynthesis of 1a–c were carried out by simple one‐pot synthesis. The resulting radiofluorinated MMP inhibitors were obtained in overall radiochemical yields of 13–43% (EOB, decay corrected) within 60–70 min (including final preparative HPLC separation). Copyright © 2002 John Wiley & Sons, Ltd.

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