ChemInform Abstract: Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors.
β Scribed by Biswanath De; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors. -A novel series of matrix metalloproteinase inhibitors such as (I) based on 1,3-piperazine is synthesized and evaluated for the inhibition of callagenase-1, stromelysin, matrilysin, and gelatinase-B. The most active compound is (Ib).