ChemInform Abstract: Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors.

✍ Scribed by S. PIKUL; ET AL. ET AL.

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199903153

✦ Synopsis

Discovery of Potent, Achiral Matrix Metalloproteinase Inhibitors.

-A novel series of matrix metalloproteinase inhibitors such as (I) based on 1,3-piperazine is synthesized and evaluated for the inhibition of callagenase-1, stromelysin, matrilysin, and gelatinase-B. The most active compound is (Ib).