𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design and Synthesis of Dual-Action Inhibitors Targeting Histone Deacetylases and 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase for Cancer Treatment

✍ Scribed by Chen, Jhih-Bin; Chern, Ting-Rong; Wei, Tzu-Tang; Chen, Ching-Chow; Lin, Jung-Hsin; Fang, Jim-Min

Book ID
120178202
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
590 KB
Volume
56
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis and stability of a carbon-14-l
Synthesis and stability of a carbon-14-labeled 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor
✍ Richard C. Burrell; Samuel J. Bonacorsi Jr.; J. Kent Rinehart; Saleem Ahmad; Khe 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 176 KB

## Abstract Inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme‐A reductase (HMGR) is an effective method of lowering plasma low‐density lipoprotein cholesterol levels. Hemi‐calcium (3R,5S,E)‐7‐(4‐(4‐fluorophenyl)‐6‐isopropyl‐2‐(methyl(1‐methyl‐1H‐1,2,4‐triazol‐5‐yl)amino)pyrimidin‐5‐yl)‐3,5‐dihydrox

ChemInform Abstract: Design and Biologic
ChemInform Abstract: Design and Biological Evaluation of a Series of Thiophene-Based 3- Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors.
✍ G. M. COPPOLA; R. E. DAMON; H. YU; R. G. ENGSTROM; T. J. SCALLEN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

Design and Biological Evaluation of a Series of Thiophene-Based 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors. -The target compounds (VII) are prepared starting from thiophenes (I) including aldol condensation and subsequent stereocontrolled reduction of the β-ketoester function to giv