Design and Biological Evaluation of a Series of Thiophene-Based 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors. -The target compounds (VII) are prepared starting from thiophenes (I) including aldol condensation and subsequent stereocontrolled reduction of the β-ketoester function to giv
Design and biological evaluation of a series of thiophene-based 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
✍ Scribed by Gary M. Coppola; Robert E. Damon; Harvey Yu; Robert G. Engstrom; Terrence J. Scallen
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 277 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Within the last few years considerable evidence has accumulated which indicates that changes in HMG-CoA reductase are due primarily, if not solely, to changes in enzyme quantity. These include the changes caused by insulin, glucagon, cholesterol, mevalonolactone, cholestyramine, compactin, cyclic mo
## Abstract Inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme‐A reductase (HMGR) is an effective method of lowering plasma low‐density lipoprotein cholesterol levels. Hemi‐calcium (3R,5S,E)‐7‐(4‐(4‐fluorophenyl)‐6‐isopropyl‐2‐(methyl(1‐methyl‐1H‐1,2,4‐triazol‐5‐yl)amino)pyrimidin‐5‐yl)‐3,5‐dihydrox