✍ Scribed by G. M. COPPOLA; R. E. DAMON; H. YU; R. G. ENGSTROM; T. J. SCALLEN
No coin nor oath required. For personal study only.
Design and Biological Evaluation of a Series of Thiophene-Based 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors.
-The target compounds (VII) are prepared starting from thiophenes (I) including aldol condensation and subsequent stereocontrolled reduction of the β-ketoester function to give (VI). Among a great variety of sodium carboxylates (VII) the here pictured ones show high HMG-CoA reductase inhibitory activity. The most potent derivative is compound ( VIIb). -(COPPOLA, G. M.; DAMON,
📜 SIMILAR VOLUMES
## Abstract Inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme‐A reductase (HMGR) is an effective method of lowering plasma low‐density lipoprotein cholesterol levels. Hemi‐calcium (3R,5S,E)‐7‐(4‐(4‐fluorophenyl)‐6‐isopropyl‐2‐(methyl(1‐methyl‐1H‐1,2,4‐triazol‐5‐yl)amino)pyrimidin‐5‐yl)‐3,5‐dihydrox
## Abstract ## Objective Statins, which are used as cholesterol‐lowering agents, have pleiotropic immunomodulatory properties. Although beneficial effects of statins have been reported in autoimmune diseases, the mechanisms of these immunomodulatory effects are still poorly understood. Type I inte
ative ultracentrifugation as described by Havel et al. 16 using a Sor-Pa ˚hlsson Foundation, the Research Foundation of Malmo ¨University Hospital, the Ernold vall Oil Turbine Drive 75 ultracentrifuge (Sorvall Products, Lundstro ¨m Foundation, and the Crafoord Foundation. Wilmington, DE). A narrow d