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Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis

✍ Scribed by Jeffrey D. Winkler; Joanne M. Holland; Jiri Kasparec; Paul H. Axelsen

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
983 KB
Volume
55
Category
Article
ISSN
0040-4020

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✦ Synopsis

The efficient synthesis of both left-and right-hand halves of a constrained analog of the anticancer natural product epothilone is described. The eleven-membered rings common to both compounds are prepared by olefin metathesis.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Synthesis of the C7
ChemInform Abstract: Synthesis of the C7β€”C17 Segment of Epothilones by a 10-Membered Ring Closing Metathesis Reaction.
✍ K. GERLACH; M. QUITSCHALLE; M. KALESSE πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

ChemInform Abstract: Total Synthesis of
ChemInform Abstract: Total Synthesis of Oxazole- and Cyclopropane-Containing Epothilone A Analogues by the Olefin Metathesis Approach.
✍ K. C. NICOLAOU; H. VALLBERG; N. P. KING; F. ROSCHANGAR; Y. HE; D. VOURLOUMIS; C. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 39 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

The synthesis of highly functionalized s
The synthesis of highly functionalized seven-membered allyl ethers using palladium-catalyzed alkoxyallylation of activated olefins and ring-closing olefin metathesis
✍ Roger L Xie; James R Hauske πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 83 KB

The investigation of palladium-catalyzed alkoxyallylation of activated olefins, followed by ring-closing metathesis to synthesize functionalized seven-membered ring allyl ethers is described. The influence of the olefin substituents on the diastereoselectivity of the alkoxyallylation has also been e