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Design and Synthesis of Celecoxib and Rofecoxib Analogues as Selective Cyclooxygenase-2 (COX-2) Inhibitors: Replacement of Sulfonamide and Methylsulfonyl Pharmacophores by an Azido Bioisostere

✍ Scribed by Habeeb, Amgad G.; Praveen Rao, P. N.; Knaus, Edward E.

Book ID: 120182637
Publisher: American Chemical Society
Year: 2001
Tongue: English
Weight: 127 KB
Volume: 44
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm010153c

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## Abstract A group of 1,2‐diphenyl‐3,5‐dioxopyrazolidines possessing a methylsulfonyl (**11**) or sulfonamide (**15**) substituent at the __para__ position of the __N__^1^‐phenyl ring, in conjunction with a hydrogen, methyl or fluoro sub‐stituent at the __para__ position of the __N__^2^‐phenyl rin