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Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors

โœ Scribed by Chandna, Nisha; Kumar, Satish; Kaushik, Pawan; Kaushik, Dhirender; Roy, Somendu K.; Gupta, Girish K.; Jachak, Sanjay M.; Kapoor, Jitander K.; Sharma, Pawan K.


Book ID
120527398
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
869 KB
Volume
21
Category
Article
ISSN
0968-0896

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โœ Md. Jashim Uddin; P. N. Praveen Rao; Edward E. Knaus ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 758 KB

A group of rofecoxib analogs, having a sulfonylazide (SO 2 N 3 ) substituent in place of the methanesulfonyl (SO 2 CH 3 ) pharmacophore at the meta-position viz 3-( 4-methyl, 4-methoxy, or 4-ethoxyphenyl)-4-(3-sulf o n y l a z i d o p h e n y l ) -2 ( 5H)furanone (7 a -c) and p a r a-position v i z