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Synthesis of 4-Alkyl-1,2-diphenyl-3,5-dioxopyrazolidines Possessing Aryl Methylsulfonyl and Sulfonamide Pharmacophores for Evaluation as Selective Cyclooxygenase-2 (COX-2) Inhibitors.

✍ Scribed by M. Abdur Rahim; P. N. Praveen Rao; Edward E. Knaus

Publisher
John Wiley and Sons
Year
2003
Weight
169 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of 4-alkyl-1,2-diphenyl-3,5-di
Synthesis of 4-alkyl-1,2-diphenyl-3,5-dioxopyrazolidines possessing aryl methylsulfonyl and sulfonamide pharmacophores for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors
✍ M. Abdur Rahim; P. N. Praveen Rao; Edward E. Knaus 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 62 KB

## Abstract A group of 1,2‐diphenyl‐3,5‐dioxopyrazolidines possessing a methylsulfonyl (**11**) or sulfonamide (**15**) substituent at the __para__ position of the __N__^1^‐phenyl ring, in conjunction with a hydrogen, methyl or fluoro sub‐stituent at the __para__ position of the __N__^2^‐phenyl rin