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Design and Synthesis of Antitumor Acylfulvenes

โœ Scribed by McMorris, Trevor C.; Yu, Jian; Hu, Yi; Estes, Leita A.; Kelner, Michael J.


Book ID
127026514
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
199 KB
Volume
62
Category
Article
ISSN
0022-3263

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While sesquiterpene illudins M and S (1 and 2, respectively) are highly cytotoxic compounds isolated from Omphalotus illudens, a semisynthetic derivative, (ร€)-irofulven (4; hydroxymethyl acylfulvene (HMAF)), has recently demonstrated far superior efficacy as an antitumor agent. [1, 2] (ร€)-Irofulven