As a model for analyzing the role of charge repulsion in proteins and its shielding by the solvent, we designed a peptide of 27 amino acid residues that formed a homodimeric coiled-coil. The interface between the coils consisted of hydrophobic Leu and Val residues, and 10 Lys residues per monomer we
β¦ LIBER β¦
Design and stability of a novel coiled-coil peptide
β Scribed by Xiang Wei; Xian-Gang Zeng; Hai-Meng Zhou
- Book ID
- 116541747
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 189 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0141-8130
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## Abstract We used the principles governing the selectivity and stability of coiledβcoil segments to design and experimentally test a set of four pairs of parallel coiledβcoilβforming peptides composed of four heptad repeats. The design was based on maximizing the difference in stability between d
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