De novo design of a two-stranded coiled-coil switch peptide
β Scribed by Richard A. Kammerer; Michel O. Steinmetz
- Book ID
- 116696751
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 828 KB
- Volume
- 155
- Category
- Article
- ISSN
- 1047-8477
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The three-helix bundle is a common structural motif among natural proteins. It has been observed in numerous important proteins, such as fibrinogen, laminin, spectrin, dystrofin, hemagglutinin, and mannose binding proteins. The three-helix bundle is a simple structure in which three a-helices pack a
## Abstract We used the principles governing the selectivity and stability of coiledβcoil segments to design and experimentally test a set of four pairs of parallel coiledβcoilβforming peptides composed of four heptad repeats. The design was based on maximizing the difference in stability between d