Gold-phosphine binding to de novo designed coiled coil peptides
✍ Scribed by Anna F.A. Peacock; Gemma A. Bullen; Lee A. Gethings; Jonathan P. Williams; Frederik H. Kriel; Judy Coates
- Book ID
- 119298880
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 760 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0162-0134
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## Abstract We introduce a de novo designed peptide model system that enables the systematic study of 1) the role of a membrane environment in coiled‐coil peptide folding, 2) the impact of different domains of an α‐helical coiled‐coil heptad repeat on the interaction with membranes, and 3) the dyna
## Abstract We used the principles governing the selectivity and stability of coiled‐coil segments to design and experimentally test a set of four pairs of parallel coiled‐coil‐forming peptides composed of four heptad repeats. The design was based on maximizing the difference in stability between d