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Design and Characterization of a Homodimeric Antiparallel Coiled Coil

โœ Scribed by Gurnon, Daniel G.; Whitaker, Jennifer A.; Oakley, Martha G.

Book ID
118066704
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
127 KB
Volume
125
Category
Article
ISSN
0002-7863

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As a model for analyzing the role of charge repulsion in proteins and its shielding by the solvent, we designed a peptide of 27 amino acid residues that formed a homodimeric coiled-coil. The interface between the coils consisted of hydrophobic Leu and Val residues, and 10 Lys residues per monomer we