Two types of P1-P3-linked macrocyclic renin inhibitors containing the hydroxyethylene isostere (HE) scaffold just outside the macrocyclic ring have been synthesized. An aromatic or aliphatic substituent (P3sp) was introduced in the macrocyclic ring aiming at the S3 subpocket (S3sp) in order to optim
✦ LIBER ✦
Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors †
✍ Scribed by Bezençon, Olivier; Bur, Daniel; Weller, Thomas; Richard-Bildstein, Sylvia; Remeň, Luboš; Sifferlen, Thierry; Corminboeuf, Olivier; Grisostomi, Corinna; Boss, Christoph; Prade, Lars; Delahaye, Stéphane; Treiber, Alexander; Strickner, Panja; Binkert, Christoph; Hess, Patrick; Steiner, Beat; Fischli, Walter
- Book ID
- 123613054
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 758 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Design and synthesis of potent macrocycl
✍
Christian Sund; Oscar Belda; Daniel Wiktelius; Christer Sahlberg; Lotta Vrang; S
📂
Article
📅
2011
🏛
Elsevier Science
🌐
English
⚖ 580 KB
Structure-Based Design of Novel Potent N
✍
Hauel, Norbert H.; Nar, Herbert; Priepke, Henning; Ries, Uwe; Stassen, Jean-Mari
📂
Article
📅
2002
🏛
American Chemical Society
🌐
English
⚖ 300 KB
Design and synthesis of potent, isoxazol
✍
Pierre-André Fournier; Mélissa Arbour; Elizabeth Cauchon; Austin Chen; Amandine
📂
Article
📅
2012
🏛
Elsevier Science
🌐
English
⚖ 460 KB
Design of potent substrate-analogue inhi
✍
HUI, K.Y. ;SIRAGY, H.M. ;HABER, E.
📂
Article
📅
2009
🏛
Wiley (Blackwell Publishing)
🌐
English
⚖ 805 KB
Design and Synthesis of Potent Nonpeptid
✍
Ohkanda, Junko; Lockman, Jeffrey W.; Kothare, Mohit A.; Qian, Yimin; Blaskovich,
📂
Article
📅
2002
🏛
American Chemical Society
🌐
English
⚖ 220 KB
Rapid Identification of Potent Nonpeptid
✍
Cleo M. Salisbury; Jonathan A. Ellman
📂
Article
📅
2006
🏛
John Wiley and Sons
🌐
English
⚖ 155 KB
👁 2 views