𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design of potent substrate-analogue inhibitors of canine renin

✍ Scribed by HUI, K.Y. ;SIRAGY, H.M. ;HABER, E.


Book ID
115099398
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
805 KB
Volume
40
Category
Article
ISSN
0367-8377

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Design and synthesis of potent macrocycl
✍ Christian Sund; Oscar Belda; Daniel Wiktelius; Christer Sahlberg; Lotta Vrang; S πŸ“‚ Article πŸ“… 2011 πŸ› Elsevier Science 🌐 English βš– 580 KB

Two types of P1-P3-linked macrocyclic renin inhibitors containing the hydroxyethylene isostere (HE) scaffold just outside the macrocyclic ring have been synthesized. An aromatic or aliphatic substituent (P3sp) was introduced in the macrocyclic ring aiming at the S3 subpocket (S3sp) in order to optim

Potent new inhibitors of human renin
✍ Szelke, M.; Leckie, B.; Hallett, A.; Jones, D. M.; Sueiras, J.; Atrash, B.; Leve πŸ“‚ Article πŸ“… 1982 πŸ› Nature Publishing Group 🌐 English βš– 341 KB
The synthesis of potent marcocyclic reni
✍ Daljit S. Dhanoa; William H. Parsons; William J. Greenlee; Arthur A. Patchett πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 French βš– 319 KB

## An eflcient synthesis of a novel class of potent macrocyclic renin inhibitors exemplified by compounds 1 and 2, which involves the macrocvclization of 8 to 9 as the key step, is described. The macrocyclic design of renin inhibitors 1 and2 disclosed here incorporates (2R,3S)-3-a&o-&yclohe~l-2-hydr