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Derivatized cyclodextrins for the separation of enantiomers in capillary electrophoresis

✍ Scribed by Schmitt, Thomas ;Engelhardt, Heinz

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
501 KB
Volume
16
Category
Article
ISSN
0935-6304

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✦ Synopsis

Abstract

The use of cyclodextrin derivatives for the efficient separation of enantiomeric drugs is described. Hydroxypropylation, methylation or carboxymethylation of the cyclodextrin not only result in a better solubility of the cyclodextrin in aqueous solutions, but also favor, via additional hydrogen bonding, the stabilization of one of the cyclodextrin‐analyte complexes. The influence of the background electrolyte on peak shape is also described here. Carboxymethylated cyclodextrin can be used in similar manner to uncharged cyclodextrins at low pH values (below 4). At pH values above 5, however, its charge also allows the separation of uncharged enantiomers as in a micellar‐like system.

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## Use of cyclodextrins in capillary electrophoresis: Resolution of tramadol enantiomers Capillary zone electrophoresis was successfully applied to the enantiomeric resolution of racemic tramadol. Both uncoated and polyacrylamide-coated capillaries were tested for method optimization using either