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Deregulation of the CXCL12/CXCR4 axis in methotrexate chemotherapy–induced damage and recovery of the bone marrow microenvironment

✍ Scribed by Kristen R. Georgiou; Michaela A. Scherer; Tristan J. King; Bruce K. Foster; Cory J. Xian

Book ID
114730868
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
411 KB
Volume
93
Category
Article
ISSN
0959-9673

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## Abstract Chemotherapy‐induced bone growth arrest and osteoporosis are significant problems in paediatric cancer patients, and yet how chemotherapy affects bone growth remains unclear. This study characterised development and resolution of damage caused by acute chemotherapy with antimetabolite 5