## Abstract Chemotherapy often induces bone growth defects in pediatric cancer patients; yet the underlying cellular mechanisms remain unclear and currently no preventative treatments are available. Using an acute chemotherapy model in young rats with the commonly used antimetabolite methotrexate (
β¦ LIBER β¦
Potential role of protein deacetylase Sirt1 in methotrexate chemotherapy-induced bone and bone marrow damage
β Scribed by T. Shandala; K. Georgiou; M. Scherer; T. King; B. Foster; C. Xian
- Book ID
- 116321479
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 68 KB
- Volume
- 44
- Category
- Article
- ISSN
- 8756-3282
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## Abstract The bone marrow microenvironment regulates early B lymphopoiesis and protects leukemia cells against chemotherapy treatment, thus the microenvironment may serve as a sanctuary site for these cells. Yet, few factors that contribute to this process are known. We have explored the role of