Background. Maintenance of second remission of childhood acute lymphoblastic leukemia (ALL) with intensive chemotherapy is often unsuccessful. The major cause of treatment failure is relapse. Materials and Methods. Of 96 children with ALL who relapsed in the marrow while on or within 1 year of comp
✦ LIBER ✦
Maintenance chemotherapy for childhood acute lymphoblastic leukemia: relation of bone-marrow and hepatotoxicity to the concentration of methotrexate in erythrocytes
✍ Scribed by Kjeld Schmiegelow; Henrick Schrøder; Malgorzata K. Pulczynska; Mogens Hejl
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 524 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0344-5704
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The outcome of children with acute lymphoblastic leukemia (ALL) and bone marrow relapse has been unsatisfactory largely because of failure to prevent subsequent leukemia relapses. Ninety-six patients were enrolled and received vincristine, prednisone, L-asparaginase, and an anthracycline as reinduc