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Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein

✍ Scribed by Nielsen, Niels H; Emdin, Stefan O; Cajander, Jenny; Landberg, Göran


Book ID
110060493
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
670 KB
Volume
14
Category
Article
ISSN
0950-9232

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✍ Yan Dong; Harold L. Asch; Daniel Medina; Clement Ip; Margot Ip; Raphael Guzman; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 454 KB 👁 1 views

Decreased gelsolin and increased cyclin D1 are among the most common defects found in human and rodent breast cancers. Our purpose was to determine the frequency of concurrence of these 2 alterations in this malignancy. Our results demonstrate that gelsolin protein and mRNA were significantly reduce