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Depurination decreases fidelity of DNA synthesis in vitro

✍ Scribed by SHEARMAN, CLYDE W.; LOEB, LAWRENCE A.


Book ID
109707933
Publisher
Nature Publishing Group
Year
1977
Tongue
English
Weight
227 KB
Volume
270
Category
Article
ISSN
0028-0836

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## Abstract Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half‐lives of hours. We report here, that after 10 h at 37