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Depression of drug metabolizing activity in the human liver by interferon-α

✍ Scribed by H. Okuno; Y. Kitao; M. Takasu; H. Kano; K. Kunieda; T. Seki; Y. Shiozaki; Y. Sameshima

Publisher
Springer
Year
1990
Tongue
English
Weight
257 KB
Volume
39
Category
Article
ISSN
0031-6970

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✦ Synopsis

The depressant effect of interferon-alpha on drug metabolizing activity in the liver has been investigated in 12 patients with chronic active hepatitis B. 7-methoxy-coumarin (7-MC) O-demethylase and 7-ethoxycoumarin (7-EC) O-deethylase, in specimens obtained by liver biopsy, were measured before and after interferon treatment. 7-MC and 7-EC O-dealkylase activity were significantly reduced after interferon treatment, from 13.4 to 9.24 nmol.g-1 liver.min-1, and from 3.22 to 2.16 nmol.g-1 liver.min-1, respectively. The magnitude of the fall varied widely between individual patients. The study provides the first direct evidence that interferon-alpha can impair the activity of drug metabolizing enzymes in the human liver.

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