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Deprenyl decreases an endogenous parkinsonism-inducing compound, 1-benzyl-1,2,3,4-tetrahydroisoquinoline in mice: in vivo and in vitro studies

โœ Scribed by Yaichiro Kotake; Yoshikazu Tasaki; Masaaki Hirobe; Shigeru Ohta


Book ID
114003615
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
95 KB
Volume
787
Category
Article
ISSN
0006-8993

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1-Benzyl-1,2,3,4-tetrahydroisoquinoline,
โœ Shaik Shavali; Edward C. Carlson; John C. Swinscoe; Manuchair Ebadi ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 279 KB

## Abstract 1โ€Benzylโ€1,2,3,4โ€tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is known to cause parkinsonism in rodents and nonhuman primates. The levels of 1BnTIQ in cerebrospinal fluid of patients with Parkinson's disease (PD) were reported to be three times higher than those in control