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Chronic administration of 1-benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine in the brain, induces parkinsonism in a primate

✍ Scribed by Yaichiro Kotake; Mitsuo Yoshida; Matsuo Ogawa; Yoshikazu Tasaki; Masaaki Hirobe; Shigeru Ohta


Book ID
116126028
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
274 KB
Volume
217
Category
Article
ISSN
0304-3940

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1-Benzyl-1,2,3,4-tetrahydroisoquinoline,
✍ Shaik Shavali; Edward C. Carlson; John C. Swinscoe; Manuchair Ebadi πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 279 KB

## Abstract 1‐Benzyl‐1,2,3,4‐tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is known to cause parkinsonism in rodents and nonhuman primates. The levels of 1BnTIQ in cerebrospinal fluid of patients with Parkinson's disease (PD) were reported to be three times higher than those in control