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Biochemical and pathological study of endogenous 1-benzyl-1,2,3,4-tetrahydroisoquinoline-induced parkinsonism in the mouse

✍ Scribed by Kenji Abe; Kyoji Taguchi; Tomoko Wasai; Jin Ren; Iku Utsunomiya; Tatsumi Shinohara; Tadashi Miyatake; Takehiro Sano

Book ID
113997242
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
409 KB
Volume
907
Category
Article
ISSN
0006-8993

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1-Benzyl-1,2,3,4-tetrahydroisoquinoline,
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## Abstract 1‐Benzyl‐1,2,3,4‐tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, is known to cause parkinsonism in rodents and nonhuman primates. The levels of 1BnTIQ in cerebrospinal fluid of patients with Parkinson's disease (PD) were reported to be three times higher than those in control

Studies on Debenzylation and Photolysis
Studies on Debenzylation and Photolysis of 1-Benzyl- and 1-(β-Phenethyl)-1,2,3,4-tetrahydroisoquinolines
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## Abstract Debenzylation of 1‐(3‐benzyloxybenzyl)‐1,2,3,4‐tetrahydroisoquinolines **1**, **6**, **7** with hydrochloric acid and ethanol gave the corresponding phenolic isoquinolines **2**, **8**, **9** and tetrahydroprotoberberines **4**, **12**, **13**. Compounds **2**, **8**, **9** on photolysi