Dephosphonylation of protected deoxynucleoside and oligodeoxynucleotide H-phosphonates
β Scribed by Colin B. Reese; Cristina Visintin
- Book ID
- 104261968
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 211 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
The conversion of four 5'-O-(4,4'-dimethoxytrityl)-2'-deoxyribonucleoside 3'-H-phosphonates 1 (B---4, 5, 6 and 7) into their partially-protected nucleoside precursors 3 (B--4, 5, 6 and 7, respectively) in good isolated yields is described. The procedure used is also suitable for the dephosphonylation of protected oligonucleotide H-phosphonate blocks.
π SIMILAR VOLUMES
Polymer bound deoxynucleoside H-phosphonate diesters are used as precursors to phosphoramidate, thiophosphate and phosphate triester analogues of DNA.
**Chemistry and Application of H-Phosphonates** is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of
**Chemistry and Application of H-Phosphonates** is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of