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Dephosphonylation of protected deoxynucleoside and oligodeoxynucleotide H-phosphonates

✍ Scribed by Colin B. Reese; Cristina Visintin


Book ID
104261968
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
211 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis


The conversion of four 5'-O-(4,4'-dimethoxytrityl)-2'-deoxyribonucleoside 3'-H-phosphonates 1 (B---4, 5, 6 and 7) into their partially-protected nucleoside precursors 3 (B--4, 5, 6 and 7, respectively) in good isolated yields is described. The procedure used is also suitable for the dephosphonylation of protected oligonucleotide H-phosphonate blocks.


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