Density heterogeneities of hepatitis C virus in human sera due to the binding of β-lipoproteins and immunoglobulins

✍ Scribed by R. Thomssen; S. Bonk; A. Thiele

• Publisher: Springer-Verlag
• Year: 1993
• Tongue: English
• Weight: 387 KB
• Volume: 182
• Category: Article
• ISSN: 0300-8584
• DOI: 10.1007/bf00191948

✦ Synopsis

Heterogeneities in the density of hepatitis C virus RNA-carrying material (HCV-RNA-CM) found in human sera (1.03-1.20g/cm 3) are attributed to the binding of low-density lipoproteins and/or of IgG. In some sera HCV-RNA-CM seems to be nearly totally bound to 13-1ipoproteins and cannot be precipitated by anti-IgG (7); in others more than 95% of HCV-RNA-CM is bound to IgG and cannot be precipitated by anti-13-1ipoprotein. Furthermore, there are sera from which HCV-RNA-CM can be completely be precipitated by either anti-13lipoprotein or anti-IgG (7), pointing to a binding of the two serum proteins to the same HCV-RNA-CM. There are other sera from which HCV-RNA-CM can be partially precipitated by the one or the other antiserum, leaving behind fractions, which are bound to 13-1ipoprotein or to IgG. HCV-RNA-CM cannot be precipitated from some sera either by anti-13-1ipoprotein or by anti-IgG (7).