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Dendritic spikes in Purkinje cells of the guinea pig cerebellum studied in vitro

✍ Scribed by J. Hounsgaard; C. Yamamoto

Publisher: Springer-Verlag
Year: 1979
Tongue: English
Weight: 712 KB
Volume: 37
Category: Article
ISSN: 0014-4819
DOI: 10.1007/bf00237721

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✦ Synopsis

Extracellular spikes were recorded simultaneously from dendrites and somata of Purkinje cells in thin cerebellar sections. Spontaneously occurring dendritic spikes were biphasic with the initial phase positive. Triphasic dendritic spikes with a large negative phase appeared during electrophoretic application of glutamate. In media containing procaine, tetrodotoxin, or high concentrations of KCl, negative dendritic spikes occurred whereas soma spikes were abolished. The negative dendritic spikes were suppressed by CoCl2 or MnCl2. Electrical stimulation elicited climbing fibre responses in somata and large negative waves in dendrites. Spikes of dendritic origin were different from those reflecting electrotonic spread of soma spikes. The relation between soma spikes and active dendritic spikes is discussed.

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